12:38:10 <RRSAgent> RRSAgent has joined #dse1
12:38:10 <RRSAgent> logging to http://www.w3.org/2007/04/13-dse1-irc
12:38:21 <eneumann> rrsagent, set log world-visible
12:38:34 <eneumann> scenario draft: http://esw.w3.org/topic/HCLSIG/Drug_Safety_and_Efficacy/Scenarios/Genetic_Diagnostic_CT#preview
12:39:00 <mswietek> mswietek has joined #DSE1
12:39:10 <sdobson> linkage analysis for colon cancer contributors, would this be a whole genome scan or specific genes
12:40:21 <sdobson> probably do specific genotyping for cyp alleles
12:41:41 <sdobson> I should introduce Mike Swietek.  He works at Pfizer and is in the office with me at the moment. 
12:41:56 <sdobson> I'm just getting him familiar with the Zakim irc
12:42:26 <mswietek> mswietek has joined #DSE1
12:42:30 <eneumann> says: Hi mike
12:42:43 <mswietek> Hello Eric, my web browser crashed
12:43:02 <eneumann> this should help... http://www.w3.org/2002/01/UsingZakim
12:43:25 <mswietek> Thanks
12:43:52 <eneumann> also if you're a tekkie... http://www.w3.org/2001/12/zakim-irc-bot.html
12:44:59 <mswietek> Thanks again
12:45:06 <eneumann> for the GeneChip, I assumed looking specifically at Cyp alleles rather than whole genome-- should be more practical?
12:45:36 <sdobson> Probably but by the time we get to Phase 11B we're pretty confident we know what metabolises our compound
12:45:55 <sdobson> so we'd go with a specfic genotype test more accurate than the gene chip
12:46:20 <sdobson> we'd use the genechip for exploratory work to look at other possible snps in teh pathway
12:46:44 <sdobson> or to subset populations based on safety information, I expect
12:47:02 <sdobson> I can run this senario past a few of our clinicians to modify it. 
12:48:17 <eneumann> What is the name of the Affy-Roche CYP diagnostic chip?
12:48:56 <sdobson> amplichip I think
12:49:08 <sdobson> don't think we've used it 
12:49:48 <mswietek> Amplichip CYP 450
12:50:21 <eneumann> thanks... Kerstin is calling me on my phone-- should be interesting!
12:50:43 <sdobson> If it's just Kerstin, you and us I can send out a conference number for us
12:51:58 <eneumann> That's all we need-- Bo can't make it.--  thanks!
12:54:49 <sdobson> Numbers have been mailed to you talk in a minute
13:54:43 <eneumann> Action: add CT data re-use steph #6
13:55:25 <eneumann> action: distinguish geno screening from gene analysis
13:55:40 <eneumann> set up TC with Stan Huff 
13:55:54 <eneumann> action: set up TC with Stan Huff
13:56:15 <eneumann> action: put together DSE paper schedule
13:56:24 <eneumann> rrsagent, draft minutes
13:56:24 <RRSAgent> I have made the request to generate http://www.w3.org/2007/04/13-dse1-minutes.html eneumann
13:56:34 <eneumann> bye rrsagent
13:56:39 <eneumann> rrsagent, bye
13:56:39 <RRSAgent> I see 4 open action items saved in http://www.w3.org/2007/04/13-dse1-actions.rdf :
13:56:39 <RRSAgent> ACTION: add CT data re-use steph #6 [1]
13:56:39 <RRSAgent>   recorded in http://www.w3.org/2007/04/13-dse1-irc#T13-54-43
13:56:39 <RRSAgent> ACTION: distinguish geno screening from gene analysis [2]
13:56:39 <RRSAgent>   recorded in http://www.w3.org/2007/04/13-dse1-irc#T13-55-25
13:56:39 <RRSAgent> ACTION: set up TC with Stan Huff [3]
13:56:39 <RRSAgent>   recorded in http://www.w3.org/2007/04/13-dse1-irc#T13-55-54
13:56:39 <RRSAgent> ACTION: put together DSE paper schedule [4]
13:56:39 <RRSAgent>   recorded in http://www.w3.org/2007/04/13-dse1-irc#T13-56-15